Professor Chandra Balaratnasingam is a surgeon-scientist that undertakes clinical and lab-based research to determine the mechanisms that underlie vision loss in retinal vascular diseases. Professor Balaratnasingam received his PhD with High Distinction from The University of Western Australia for a thesis that examined pathogenic mechanisms underlying retinal ganglion cell axonal degeneration in diabetes and glaucoma.
Professor Balaratnasingam has published over 100 peer-reviewed manuscripts and his work has been editorialized in major international journals. The impact of his post-doctoral research to the field of vision science earnt him a nomination by the Australian Academy of Science to attend the 61st Annual Meeting of Nobel Laureates in Lindau, Germany. Professor Balaratnasingam serves on the editorial board of the Journals Clinical and Experimental Ophthalmology and Retina Cases and Brief Reports.
Education/academic qualifications/roles responsibilities
- MBBS (Honours) – University of Western Australia
- PhD (High Distinction) – University of Western Australia
- Fellow Royal Australian and New Zealand College of Ophthalmologists (FRANZCO)
- Editorial Board member for journal Clinical and Experimental Ophthalmology that is published on behalf of the Royal Australian and New Zealand College of Ophthalmologists.
- Editorial Board member for journal Retinal Cases and Brief Reports.
- Principal Investigator or sub-PI for a range of pharma-sponsored clinical trials.
- Advisory Board Member for Bayer and Allergan Pharmaceuticals.
Awards/Professional achievements
Academic Honours
- 2009 – Nomination by Australian Academy of Science to attend the 61st meeting of Nobel Laureates in Medicine and Physiology.
- 2011 – Recipient of the Robert Street prize. This is awarded by the University of Western Australia for the most outstanding thesis for the degree of Doctor of Philosophy for the year.
Membership to Prestigious societies (by invitation)
- Member of The Macula Society
- Member of The Retina Society
Research papers that have been editorialised
- Nicolela MT. Retinal vein pulsation predicts increasing optic disc excavation. Br J Ophthalmol 2007;91:405-406. (The significance and importance of my retinal vein pulsation work was discussed by Marcelo Nicolela in this editorial).
- Hammond BR. Foveal Morphology and the Macular Carotenoids. Invest Ophthalmol Vis Sci 2015;56(13):7866. (Dr. Billy Randall Hammond discusses the importance of my work that reported the correlation between the topological characteristics of the foveal avascular zone and the spatial profile of human macular pigments.)
- Guymer R. Cuticular drusen: Clinical phenotypes and natural history defined using multimodal imaging. Ophthalmology 2018;125(1):100-118. (Professor Robyn Guymer discussed the major contribution my paper on cuticular drusen made to the field of age related macular degeneration).
Journal issues with work appearing on the front cover
- Investigative Ophthalmology and Visual Science (August 2007)
- Brain Research (March 2009)
- Investigative Ophthalmology and Visual Science (June 2009)
- Investigative Ophthalmology and Visual Science (January 2010)
- Investigative Ophthalmology and Visual Science (June 2010)
- Investigative Ophthalmology and Visual Science (August 2015)
- Investigative Ophthalmology and Visual Science (October 2018)
- Ophthalmology Retina (2019).
Grants/scholarships/funding overview
- 2001: AMA J.G. Hunter Research Fellowship
Sponsor: Australian Medical Association
Value: $20,000
Role: Principal investigator - 2001: WB MacDonald Scholarship in Paediatrics
Sponsor: Princess Margaret Hospital for Children
Value: $15,000
Role: Principal investigator - 2002: Robert Vandongen Research Scholarship
Sponsor: Royal Perth Hospital
Value: $15,000
Role: Principal investigator - 2005-2008: Athelstan and Amy Saw Medical Research Scholarship
Sponsor: The University of Western Australia
Value: $120,000
Role: Principal investigator - 2005-2008: Medical Post-Graduate Research Scholarship
Sponsor: National Health and Medical Research Council Australia
Value: $150,000
Role: Principal investigator - 2009: ORIA/RANZCO EYE FOUNDATION GRANT
Sponsor: Ophthalmic Research Institute of Australia
Value: $180,000
Role: Sub-investigator - 2014–2015: RANZCO Eye Foundation/Bayer Medical Retina Scholarship
Sponsor: Bayer and RANZCO
Value: $50,000
Role: Principal investigator - 2014–2015: Allergan/RANZCO Study Scholarship
Sponsor: Allergan and RANZCO
Value: $15,000
Role: Principal investigator - 2014–2015: MIGA Doctors in Training Grant
Sponsor: The Medical Insurance Group
Value: $10,000
Role: Principal investigator - 2016–2017: Near-Miss Merit Grant
Sponsor: WA Department of Health
Value: $50,000
Role: Principal investigator - 2017: Ray Florence Shaw Grant
Sponsor: Sir Charles Gairdner Hospital
Value: $30,000
Role: Principal investigator - 2018–2019: Raine priming Grant
Sponsor: Raine Medical research Foundation
Value: $140,000
Role: Principal investigator - 2019-2020: Ray Florence Shaw Grant
Sponsor: Sir Charles Gairdner Hospital
Value: $30,000
Role: Principal investigator - 2019-2021: Investigator Initiated Research Grant
Sponsor: Bayer, Australia
Value: $240,000
Role: Principal investigator - 2021-2022: Equipment Grant
Sponsor: National Health and Medical research Council of Australia
Value: $50,000
Role: Co-Principal investigator - 2021-2026: Investigator Initiated Research Grant
Sponsor: Stan Perron Charitable Foundation
Value: $ 2,425,000
Role: Co-Principal investigator
Research Activity
Professor Balaratnasingam’s research is focused on understanding the mechanisms leading to vision loss in diabetic retinopathy. Diabetes mellitus is a silent pandemic in Australia and remains an important cause of irreversible vision loss in the working-age population. Professor Balaratnasingam combines his clinical expertise as a retina specialist together with laboratory-based investigational techniques to identify diagnostic and treatment strategies for diabetic retinopathy.
His research in the field of diabetic retinopathy follows three major streams:
- Understanding early biomarkers of retinal injury in diabetes though longitudinal study and non-invasive clinical imaging.
- Unravelling pathogenic mechanisms underlying neural-vascular-glial degeneration in diabetic retinopathy using laboratory techniques.
- Evaluating new treatment strategies for the retinal complications of diabetes through clinical trial.