Auto-antibodies against retinal protein are commonly found in patients with retinal diseases. There is much uncertainty in the interpretation of results of anti-retinal autoantibody (ARA) tests due to overlaps in clinical syndromes and antibody profiles across different disease processes. To clarify the role of ARA in retinal diseases, our group is studying ARA profiles in healthy controls and patients with macular degeneration, inherited retinal diseases and autoimmune retinopathy.